Werner Siegmund Selected Research

talinolol

1/2019	Transcriptional and Post-Transcriptional Regulation of Duodenal P-Glycoprotein and MRP2 in Healthy Human Subjects after Chronic Treatment with Rifampin and Carbamazepine.
9/2004	Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.
2/2002	Stereoselective disposition of talinolol in man.

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Werner Siegmund Research Topics

Disease

5	Body Weight (Weight, Body) 08/2007 - 02/2002
3	Infections 01/2021 - 05/2007
3	Pain (Aches) 01/2019 - 03/2015
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2015 - 07/2003
2	Chemical and Drug Induced Liver Injury 01/2019 - 01/2019
2	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2007
2	Constipation 02/2016 - 12/2011
2	Myalgia 03/2015 - 10/2014
2	Overactive Urinary Bladder (Overactive Bladder) 11/2012 - 05/2010
2	Heart Failure 08/2007 - 03/2004
2	Alzheimer Disease (Alzheimer's Disease) 05/2004 - 10/2002
1	Neuralgia (Stump Neuralgia) 01/2021
1	Seizures (Absence Seizure) 01/2019
1	Epilepsy (Aura) 01/2019
1	Lung Diseases (Lung Disease) 03/2016
1	Opioid-Induced Constipation 02/2016
1	Neuroblastoma 01/2016
1	Sexually Transmitted Diseases (Sexually Transmitted Disease) 01/2016
1	Myotoxicity 10/2014
1	Atrial Fibrillation 04/2013
1	Drug-Related Side Effects and Adverse Reactions 04/2013
1	Hemorrhage 04/2013
1	Wounds and Injuries (Trauma) 04/2013
1	Hyperhidrosis 11/2012
1	Sialorrhea 11/2012
1	Urinary Incontinence 05/2010
1	Neoplasms (Cancer) 04/2010
1	Malaria 11/2009
1	Dyslipidemias (Dyslipidemia) 05/2009
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2009
1	Choriocarcinoma 02/2009
1	Drug Resistant Epilepsy 09/2008

Drug/Important Bio-Agent (IBA)

8	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019 - 09/2002
5	Pharmaceutical PreparationsIBA 01/2021 - 04/2010
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 10/2002
4	Messenger RNA (mRNA)IBA 09/2008 - 09/2002
3	flupirtineIBA 01/2019 - 03/2015
3	Opioid Analgesics (Opioids)IBA 01/2019 - 12/2011
3	talinololIBA 01/2019 - 02/2002
3	Rifampin (Rifampicin)FDA LinkGeneric 01/2019 - 02/2002
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 05/2007
2	Multidrug Resistance-Associated Protein 2IBA 01/2019 - 09/2004
2	Analgesics (Analgesic Drugs)IBA 01/2019 - 03/2015
2	Carbamazepine (Tegretol)FDA LinkGeneric 01/2019 - 09/2004
2	methylnaltrexone FDA Link 02/2016 - 12/2011
2	CytokinesIBA 01/2016 - 09/2003
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2015 - 05/2009
2	Peptides (Polypeptides)IBA 04/2010 - 10/2002
2	RNA (Ribonucleic Acid)IBA 09/2004 - 09/2002
1	TabletsIBA 01/2021
1	Dosage Forms (Dosage Form)IBA 01/2021
1	Ketamine FDA LinkGeneric 01/2021
1	ezogabine (retigabine)IBA 01/2019
1	Ezetimibe (Zetia)FDA Link 01/2019
1	Therapeutic UsesIBA 01/2019
1	MicroRNAs (MicroRNA)IBA 01/2019
1	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 01/2019
1	Clarithromycin (Biaxin)FDA LinkGeneric 03/2016
1	Sulfapyridine FDA Link 02/2016
1	LaxativesIBA 02/2016
1	Radio-Opaque acrylic resinIBA 02/2016
1	Sulfasalazine (Azulfidine)FDA LinkGeneric 02/2016
1	Lactulose (Duphalac)FDA LinkGeneric 02/2016
1	Loperamide (Imodium)FDA LinkGeneric 02/2016
1	dinutuximabIBA 01/2016
1	Interleukin-2 (IL2)IBA 01/2016
1	Creatine Kinase (Creatine Phosphokinase)IBA 10/2014
1	Telmisartan (Micardis)FDA Link 10/2014
1	Fluvastatin FDA Link 10/2014
1	Biomarkers (Surrogate Marker)IBA 05/2014
1	Phenprocoumon (Liquamar)FDA Link 04/2013
1	Methantheline (Banthine)FDA Link 11/2012
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 11/2012
1	Narcotic Antagonists (Opioid Antagonists)IBA 12/2011
1	Muscarinic AntagonistsIBA 05/2010
1	propiverineIBA 05/2010
1	AnionsIBA 04/2010
1	Hormones (Hormone)IBA 04/2010
1	VaccinesIBA 11/2009
1	Antigen-Antibody Complex (Immune Complex)IBA 11/2009
1	AntigensIBA 11/2009
1	AllergensIBA 11/2009
1	Merozoite Surface Protein 1 (MSA1)IBA 11/2009
1	AcidsIBA 11/2009
1	NucleotidesIBA 03/2009
1	Histone Deacetylase InhibitorsIBA 02/2009
1	Calcitriol Receptors (Calcitriol Receptor)IBA 02/2009
1	Retinoid X Receptor alphaIBA 02/2009
1	Butyric Acid (Butanoic Acid)IBA 02/2009
1	1,25-dihydroxyvitamin DIBA 02/2009
1	Digitalis GlycosidesIBA 08/2007
1	Digitoxin FDA Link 08/2007
1	tulathromycinIBA 05/2007
1	Glutathione (Reduced Glutathione)IBA 01/2007
1	Cyclic NucleotidesIBA 01/2007
1	multidrug resistance-associated protein 1IBA 01/2007

Therapy/Procedure

2	Therapeutics 01/2021 - 09/2008
1	Intravenous Infusions 01/2021
1	Secondary Prevention 01/2015
1	Analgesia 12/2011